N-Terminal Actin-Binding Site of Lmod2 Promotes Controlled Pointed End Elongation
These discoveries support a model of controlled thin filament pointed end elongation by Lmod2 and provide the first direct evidence of, as well as the structural and functional mechanistic basis for, Lmod2's physiological leaky cap activity.
Authors
- Thomas A. Bunch (ORCID: https://orcid.org/0000-0002-6237-1427)
- Tania M. Larrinaga (ORCID: https://orcid.org/0000-0002-4091-1808)
- Brett A. Colson (ORCID: https://orcid.org/0000-0002-5721-4320)
- Christopher T. Pappas (ORCID: https://orcid.org/0000-0002-7475-6949)
- Garry E. Smith (ORCID: https://orcid.org/0000-0001-9544-0938)
- Timothy J. Rast
- Dmitri Tolkatchev (ORCID: https://orcid.org/0000-0002-1300-6458)
- Alla S. Kostyukova (ORCID: https://orcid.org/0000-0002-6724-2069)
- Carol C. Gregorio
Institutions
- University of Arizona (US)
- Washington State University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1161/circresaha.125.327013
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00