Tuft-cell-derived IL-25 regulates intestinal ILC2 in response to Brucella infection
These findings confirm that the activation of the tuft cell-ILC2 circuit is dependent on the regulatory role of IL-25. These findings extend the antimicrobial role of the tuft cell-ILC2 circuit beyond parasitic immunity and identify IL-25 as an essential regulatory mediator in antibacterial defense at the intestinal mucosa.
Authors
- F B Zhang
- Na Chen (ORCID: https://orcid.org/0000-0002-3611-7804)
- Kaiyu Shang (ORCID: https://orcid.org/0009-0009-2629-7643)
- YueJie Zhu
- Xinxin Qi
- Tingting Tian
- Huidong Shi
- Juan Shi
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1732274
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00