Gut microbiota and metabolomic changes across preterm stages: potential associations with bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity in preterm infants, yet early biomarkers and targeted preventive strategies are limited. By integrating microbiome and metabolome data from a pilot cohort, this study identified patterns of disrupted Bacteroidota succession and <i>Streptococcus</i>-associated oxidative stress that are associated with BPD risk. These findings highlight the gut as a potential extrapulmonary contributor to disease susceptibility and support early risk assessment and guide future microbiome-targeted interventions in preterm infants.
Authors
- Huaiyuan Yin (ORCID: https://orcid.org/0000-0003-2542-5008)
- Li Zhang (ORCID: https://orcid.org/0009-0003-0682-4027)
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Mingzhao Han
- Danhong Wang (ORCID: https://orcid.org/0000-0002-4727-0345)
- Lixia Zhou
- Chunfang Gu
- Guozhen Jian
- Qiongyu Qin
- Peng Li
- Dong Cai
Institutions
- Central South University (CN)
- Hainan Normal University (CN)
- Hainan Modern Women and Children's Hospital (CN)
- Hainan General Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1128/spectrum.02740-25
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China