Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma
DMMR occurs in a minority of ACC, often without MSI. Although Lynch syndrome accounts for a subset of cases, dMMR is not predictive of clinical features or ICI response. Nonetheless, MMR testing remains important for identifying individuals at hereditary cancer risk.
Authors
- M-V. Teleanu
- L-S. Landwehr
- CL Ronchi
- S. Kircher
- R.C. Bargou
- O. Kimpel
- M. Reuter
- B. Altieri
- S. Appenzeller
- A. Stenzinger
- M. Fassnacht
- H. Glimm
- M. Kroiss
- J. Lippert
- H. Remde
- A. Jahn
- S. Fröhling
- S. Herterich
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- Comprehensive Cancer Center Mainfranken (DE)
- National Center for Tumor Diseases (DE)
- Universitätsklinikum Würzburg (DE)
- University Hospital Carl Gustav Carus (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.106030
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 36.00
Funders
- Deutsche Forschungsgemeinschaft
- Nationales Centrum für Tumorerkrankungen Heidelberg
- Deutschen Konsortium für Translationale Krebsforschung