Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer

Aneuploidy is prevalent across human cancers, yet its specific contributions to tumor evolution remain poorly understood. In this issue, Cross, Nowinski, Cresswell, Mossner, and colleagues present a longitudinal analysis of 755 samples from 167 patients with colorectal cancer, uncovering the temporal dynamics of karyotype evolution in this tumor type. See related article by Cross et al., p. 218.

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Publication Details

Journal
Cancer Discovery
Published
2026-02-06
DOI
https://doi.org/10.1158/2159-8290.cd-25-1430
Primary Topic
Microtubule and mitosis dynamics
Type
article
Field-Weighted Citation Impact
0.00
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article

Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer

Rachel Slutsky, Uri Ben-David, Hajime Okada
Cancer Discovery
Microtubule and mitosis dynamics
article

Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer

Rachel Slutsky, Uri Ben-David, Hajime Okada
article en

Abstract

Aneuploidy is prevalent across human cancers, yet its specific contributions to tumor evolution remain poorly understood. In this issue, Cross, Nowinski, Cresswell, Mossner, and colleagues present a longitudinal analysis of 755 samples from 167 patients with colorectal cancer, uncovering the temporal dynamics of karyotype evolution in this tumor type. See related article by Cross et al., p. 218.

Cancer DiscoveryVol. 16(2)
Tel Aviv University (IL)
Good health and well-being
Openalex Percentile: Top 67%
Microtubule and mitosis dynamics
DOISourceOpenAlex
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Holding the Line: Negative Selection Maintains the Karyotype in Metastatic Colorectal Cancer — Rachel Slutsky, Uri Ben-David, et al. · Cancer Discovery (2026) | TGRS Research Map | TGRS