Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis
EGFR mutation discordance is common and clinically relevant, particularly in NSCLC, but varies substantially by sampling strategy, biofluid, treatment context, and metastatic site. Given the high between-study heterogeneity and the predominance of NSCLC and Asian cohorts, pooled estimates should be interpreted as descriptive summaries rather than universally generalisable benchmarks. These findings support integrated and context-aware sampling strategies for EGFR-targeted therapy and resistance monitoring.
Authors
- Stevie van der Mierden (ORCID: https://orcid.org/0000-0001-7080-1872)
- Winnie Schats (ORCID: https://orcid.org/0000-0003-1470-9515)
- Zuhir Bodalal (ORCID: https://orcid.org/0000-0002-2617-8128)
- Pétur Snæbjörnsson (ORCID: https://orcid.org/0000-0002-1086-8108)
- Olga Maxouri (ORCID: https://orcid.org/0000-0002-4709-1929)
- Diana Ivonne Rodríguez Sánchez
- Stephan Ursprung
- Selin Asli Öztürk
- Sajjad Rostami
Institutions
- University of Iceland (IS)
- University of Southern Denmark (DK)
- Maastricht University Medical Centre (NL)
- The Netherlands Cancer Institute (NL)
- Maastricht University (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Molecular Diagnosis & Therapy
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1007/s40291-026-00829-6
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00