Adipose dysfunction, lipid dysregulation, and adipokines in sarcopenia: a systematic review and meta-analysis with sex-specific analyses
This meta-analysis integrates lipid fractions, adipokines, adiposity markers, and sex-specific differences in sarcopenia. Our findings highlight the significant rise in HDL-C in females and suggest the need for sex-targeted interventions. Further longitudinal studies are needed to clarify causality and refine clinical practice in sarcopenia management. The protocol was registered on PROSPERO (CRD42024626636).
Authors
- M Rahmati
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Laurent Boyer (ORCID: https://orcid.org/0000-0002-1375-1706)
- Mahamat Hassan Yacoub Hassan
- Awil Abdi Wehliye
- Djandan Tadum Arthur Vithran
- Wenfeng Xiao
Institutions
- Ceres (US)
- Central South University (CN)
- Aix-Marseille Université (FR)
- Vali Asr University of Rafsanjan (IR)
- Lorestan University (IR)
- Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille (FR)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Age and Ageing
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1093/ageing/afag020
- Citations
- 1
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 32.84