Ultrasound-Enhanced Delivery of the Quercetin Derivative ANL3 Activates the <i>FOXO1A</i> – <i>NDRG2</i> – <i>SOD2</i> Axis to Induce Endoplasmic Reticulum Stress in Osteosarcoma
These findings show that ultrasound-augmented ANL3 treatment is a viable biotherapeutic method for osteosarcoma because it improves ER stress-mediated tumor suppression while reducing systemic adverse effects. This article proposes a mechanistic framework for incorporating ultrasound-mediated medication activation into precision cancer biotherapy.
Authors
- Jun Qian (ORCID: https://orcid.org/0000-0002-2649-8121)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Chang Shu (ORCID: https://orcid.org/0000-0002-3730-5102)
- Wangsheng Wu
- Bingsheng Liu
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
- Quzhou University (CN)
Publication Details
- Journal
- Cancer Biotherapy and Radiopharmaceuticals
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1177/10849785251406063
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00