Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway
Collectively, we have developed a unique genetic signature that is based on genes associated with calcium signaling. This signature possesses the capacity to precisely anticipate the survival prognosis and therapeutic response of BLCA patients and might have a crucial role in guiding clinical treatment. Furthermore, ATP2B4 has been identified as a crucial oncogenic gene. The downregulation of ATP2B4 leads to mitochondrial Ca<sup>2+</sup> overload, ultimately resulting in apoptosis of BLCA cells.
Authors
- Mengyao Li (ORCID: https://orcid.org/0000-0001-7988-8759)
- Ding Qiannan
- w wang
- Y. Li
- Yu Gong (ORCID: https://orcid.org/0000-0001-7415-6524)
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Lulu Zhang (ORCID: https://orcid.org/0000-0002-8284-5781)
- Xiurong Wang
Institutions
- Fujian Medical University (CN)
- Shaoxing University (CN)
- Jiangxi Provincial People's Hospital (CN)
- Third Hospital of Nanchang (CN)
- Shaoxing No.6 People's Hospital (CN)
- Second Hospital of Nanchang (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1561666
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00