Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence
This study reveals that KAT8-mediated acetylation of CISD2 at K74 preserves mitochondrial homeostasis by inhibiting ubiquitin-mediated degradation, representing a critical mechanism for counteracting cellular senescence. Ginsenoside Rg5 acts as a KAT8 agonist to target and activate this pathway, thereby providing a novel strategy for anti-aging intervention.
Authors
- Xueli Cui (ORCID: https://orcid.org/0000-0003-2698-7707)
- Feiran Yu
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Qingzhi Zhao
- Chengyu Cai (ORCID: https://orcid.org/0009-0002-6595-1176)
- Jingji Jin (ORCID: https://orcid.org/0000-0001-9432-5954)
- Yuzhu Wang (ORCID: https://orcid.org/0009-0009-3416-316X)
- Yong Cai
- Na Zhang
- Tiantian Xu
- Haoqing Dou
- Jinmeng Chu
Institutions
- Jilin University (CN)
- Jilin Jianzhu University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1016/j.phymed.2026.157923
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00