Impact of a high-protein diet with and without strength training over 17 weeks on the plasma metabolome in older adults

A high-protein diet, alone or combined with resistance training, induces modest but measurable metabolic shifts without disrupting global metabolic homeostasis. These findings suggest that older adults can adapt to elevated protein intake while maintaining metabolic stability, supporting the metabolic safety of a high-protein diet in combination with resistance exercise. https://clinicaltrials.gov (NCT04023513).

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Publication Details

Journal
Age and Ageing
Published
2026-01-21
DOI
https://doi.org/10.1093/ageing/afag010
Primary Topic
Muscle metabolism and nutrition
Type
article
Field-Weighted Citation Impact
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article

Impact of a high-protein diet with and without strength training over 17 weeks on the plasma metabolome in older adults

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Age and Ageing
Muscle metabolism and nutrition
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Impact of a high-protein diet with and without strength training over 17 weeks on the plasma metabolome in older adults

Sandra Unterberger, B. Franzke, Eva-Maria Strasser, Rudolf Aschauer, Agnes Draxler, Barbara Wessner, Karl-Heinz Wagner, Hannah Spahits, Patrick Alexander Zöhrer, Ammar Tahir
article en

Abstract

A high-protein diet, alone or combined with resistance training, induces modest but measurable metabolic shifts without disrupting global metabolic homeostasis. These findings suggest that older adults can adapt to elevated protein intake while maintaining metabolic stability, supporting the metabolic safety of a high-protein diet in combination with resistance exercise. https://clinicaltrials.gov (NCT04023513).

Age and AgeingVol. 55(2)
University of Vienna (AT), Hochschule Campus Wien (AT), Tirol Kliniken (AT)
Openalex Percentile: Top 67%
Muscle metabolism and nutrition
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