Postpartum reversible cerebral vasoconstriction syndrome: a rare but severe cause of postpartum headache

Postpartum reversible cerebral vasoconstriction syndrome (RCVS), also known as postpartum cerebral angiopathy, is an uncommon but potentially serious cause of thunderclap headache. Early diagnosis is challenging, and there may be a misdiagnosis due to non-specific clinical presentation and frequently normal initial imaging studies.We report a case of a primigravid woman in her early 30s who developed a sudden, severe holocranial headache on the fourth postpartum day, with no associated neurological findings. Initial head CT, CT angiography, cerebral CT venography and MRI showed no abnormalities. However, digital subtraction angiography (DSA), revealed multifocal segmental narrowing of intracranial arteries, with complete reversibility after 3 months, consistent with RCVS.The patient was treated with oral nimodipine and experienced gradual symptom resolution. There was no complication associated, with no recurrence so far.

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Publication Details

Journal
BMJ Case Reports
Published
2026-02-01
DOI
https://doi.org/10.1136/bcr-2025-269353
Primary Topic
Neurological Complications and Syndromes
Type
article
Field-Weighted Citation Impact
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article

Postpartum reversible cerebral vasoconstriction syndrome: a rare but severe cause of postpartum headache

Carolina Heitmann Mares Azevedo Ribeiro, Neha Ramniclal
BMJ Case Reports
Neurological Complications and Syndromes
article

Postpartum reversible cerebral vasoconstriction syndrome: a rare but severe cause of postpartum headache

Carolina Heitmann Mares Azevedo Ribeiro, Neha Ramniclal
article en

Abstract

Postpartum reversible cerebral vasoconstriction syndrome (RCVS), also known as postpartum cerebral angiopathy, is an uncommon but potentially serious cause of thunderclap headache. Early diagnosis is challenging, and there may be a misdiagnosis due to non-specific clinical presentation and frequently normal initial imaging studies.We report a case of a primigravid woman in her early 30s who developed a sudden, severe holocranial headache on the fourth postpartum day, with no associated neurological findings. Initial head CT, CT angiography, cerebral CT venography and MRI showed no abnormalities. However, digital subtraction angiography (DSA), revealed multifocal segmental narrowing of intracranial arteries, with complete reversibility after 3 months, consistent with RCVS.The patient was treated with oral nimodipine and experienced gradual symptom resolution. There was no complication associated, with no recurrence so far.

BMJ Case ReportsVol. 19(2)
Hospital de Egas Moniz (PT), Hospital of St. Francis Xavier (PT)
Good health and well-being
Openalex Percentile: Top 67%
Neurological Complications and Syndromes
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