Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion
In our cohort, prolonged albumin infusion did not lead to a difference in intravascular fluid volume, but it resulted in the loss of ~ 60% of the infused albumin and ascites development. Ascites was associated with lower end-expiratory lung gas volume and higher elastance, despite similar histological lung damage across the groups.
Authors
- Francesca Collino (ORCID: https://orcid.org/0000-0001-6434-2657)
- Chiara Sonzogni
- Simone Gattarello (ORCID: https://orcid.org/0000-0002-5047-9246)
- Mattia Busana (ORCID: https://orcid.org/0000-0002-1626-1278)
- Federica Romitti (ORCID: https://orcid.org/0000-0003-1827-9524)
- Martina Caronna
- Alessandro Gatta
- Luciano Gattinoni (ORCID: https://orcid.org/0000-0001-5380-2494)
- Walter Gallese
- Domenico Nocera (ORCID: https://orcid.org/0009-0005-6833-7480)
- Luigi Camporota
- Beatrice Donati
- Stefano Giovanazzi
- Ilaria Grava
- Carlo Chiumiento
- Emanuele Rollo (ORCID: https://orcid.org/0009-0009-5361-574X)
- Michael Quintel
- Onnen Moerer
- Aurelio Sonzogni
- Gaetano Gazzé
- Zhe Li
Institutions
- University of Bergamo (IT)
- University of Salerno (IT)
- King's College London (GB)
- University of Milan (IT)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Renji Hospital (CN)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Universitätsmedizin Göttingen (DE)
- Azienda Socio Sanitaria Territoriale Bergamo Est
- University of Bari Aldo Moro (IT)
- University of Göttingen (DE)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s40635-026-00853-0
- Citations
- 1
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- European Society of Intensive Care Medicine
- Grifols