Deciphering the Genomic Landscape of Oropharyngeal Squamous Cell Carcinoma: Distinct Mutation Patterns in Disease
This study identifies distinct genomic signatures in OPSCC subgroups, highlighting candidate biomarkers in pathways like PI3K/AKT signaling that warrant further investigation. Validating these markers in prospective trials is a critical next step to translate these findings into personalized therapeutic strategies for OPSCC patients.
Authors
- Pedro S. Bonilla (ORCID: https://orcid.org/0000-0003-2984-3004)
- Vinay Veluvolu (ORCID: https://orcid.org/0000-0003-2773-9465)
- Abubakar Tauseef (ORCID: https://orcid.org/0000-0002-4317-1868)
- Aliasgher Khaku
- Gabriel Bitar
- Saif Alshaka
- Vijay A. Patel
- Eli Oved
- Hassan Nur
- Nathan Tran
- Bhavish Aubeelauck
- Beau Hsia
Institutions
- Creighton University (US)
- Texas Tech University (US)
- University of Illinois Urbana-Champaign (US)
- Illinois College (US)
- Moffitt Cancer Center (US)
- University of Nebraska at Kearney (US)
- Rady Children's Hospital-San Diego (US)
- Michigan State University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Life
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3390/life16020282
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00