Quantitative in vivo Cherenkov luminescence imaging and dosimetry of 86Y-NM600
With appropriate depth-dependent optical attenuation calibration and Monte Carlo-derived ionizing scatter correction, CLI can provide quantitative biodistribution and dosimetry estimates comparable to PET. This approach enables high-throughput, low-cost in vivo dosimetry, expanding the feasibility of large-scale preclinical RPT studies and supporting translational radiopharmaceutical development.
Authors
- Sydney Jupitz (ORCID: https://orcid.org/0000-0001-9104-8920)
- Malick Bio Idrissou (ORCID: https://orcid.org/0009-0001-0437-6668)
- Bryan P. Bednarz (ORCID: https://orcid.org/0000-0002-7467-9816)
- Brian W. Pogue (ORCID: https://orcid.org/0000-0002-9887-670X)
- Aubrey Parks
- Campbell Haasch
- Reinier Hernandez
Institutions
- Dartmouth College (US)
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1186/s40658-026-00836-w
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00