Understanding risk of poor outcomes in adults hospitalised with respiratory syncytial virus infection: evidence from a multicentre UK cohort
In adults hospitalised with RSV-associated ARI, simple age-based heuristics-including the UK ≥75-year threshold-showed only modest ability to discriminate risk of ICU/HDU admission/60-day mortality once hospitalised. Comorbidity-inclusive approaches may provide more informative hospital-level risk stratification and warrant evaluation in future RSV vaccine-effectiveness and outcome studies. Any application requires external validation, more systematic RSV testing and comparison with physiology-based scores in larger, vaccinated cohorts.
Authors
- George Hulston
- Dexter Wiseman (ORCID: https://orcid.org/0000-0002-6398-7450)
- Sarah Denny (ORCID: https://orcid.org/0000-0002-8248-6053)
- Karl J. Staples (ORCID: https://orcid.org/0000-0003-3844-6457)
- J Panaguiton
- Martha Purcell (ORCID: https://orcid.org/0000-0002-9913-9971)
- Alex Allen (ORCID: https://orcid.org/0000-0002-6998-447X)
- Abigail Jones
- Huw Ellis (ORCID: https://orcid.org/0000-0002-4351-1658)
- Matthew Pavitt (ORCID: https://orcid.org/0000-0001-9390-3070)
- Philip Mitchelmore (ORCID: https://orcid.org/0000-0002-7850-3068)
- Tom Wilkinson (ORCID: https://orcid.org/0000-0003-1771-3851)
- Cyrus Daneshvar (ORCID: https://orcid.org/0000-0003-0956-8674)
- TW Clark
- Stefan John Marciniak (ORCID: https://orcid.org/0000-0001-8472-7183)
- Rachel Patel (ORCID: https://orcid.org/0000-0003-4592-0815)
- Anna Freeman (ORCID: https://orcid.org/0000-0002-8193-0319)
- James Myerson
- A Lea
- Paul Hong Lee
- Hans Siy-yap
- Anluan Keating
- Pedro Rodrigues
- James D. Chalmers
- Ida Saidy
- Emma A Davies
- Tommaso Morelli
- Michael G Crooks
- Tom Lewis
- Sharon Weinberg
- Aruna T Bansal
Institutions
- St Thomas' Hospital (GB)
- University of Leicester (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Royal Papworth Hospital (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Ninewells Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Manchester University NHS Foundation Trust (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- Plymouth Hospital (GB)
- University Hospitals Plymouth NHS Trust (GB)
- University of Southampton (GB)
- Imperial College London (GB)
- Hull York Medical School (GB)
Publication Details
- Journal
- Thorax
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1136/thorax-2025-224192
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 31.52
Funders
- University of Southampton