HMPA-Enabled Direct γ′-Arylation of Cyclic Vinylogous Esters
Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ'-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba)<sub>2</sub>/cataCXium A and hexamethylphosphoramide (HMPA) as a regioselectivity-governing additive. The method accommodates a broad range of (hetero)aryl bromides and CVE substrates. The resulting γ'-aryl CVEs were further converted to α-arylcycloalkenones via Stork-Danheiser transposition.
Authors
- Yen‐Ku Wu (ORCID: https://orcid.org/0000-0002-9269-7444)
- Yan-Xun Li
- Wei-Ting Zhao
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chung Yuan Christian University (TW)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1021/acs.orglett.6c00380
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00