Thalamic GABA+ levels are negatively associated with neuropsychiatric symptoms in patients with insomnia
Our results revealed alterations in the levels of GABA+ and GPC in the thalamus of patients with insomnia. These findings provide objective neurochemical evidence for the pathophysiological mechanisms of insomnia.
Authors
- Dongyuan Xu (ORCID: https://orcid.org/0000-0002-3055-6320)
- Mingyuan Dai
- Gen Yan
- Huande Hong
- Rui Wang
- Yumeng Mao
- Yanlong Jia
Institutions
- Yanbian University (CN)
- Shantou University (CN)
- Wuhan University (CN)
- Fifth Hospital of Shijiazhuang (CN)
- Hubei University of Arts and Science (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- Fifth Hospital In Wuhan (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fnhum.2026.1750271
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Science and Technology Program of Hubei Province