Disease‐causing <i>STAT3</i> variants can be discriminated by a functional flow cytometry test
Determination of the IL-10 mediated, STAT3-dependent TNFα inhibition ratio in PBMC-derived monocytes by flow cytometry is a sensitive and specific method to functionally assess and discriminate STAT3-DN, -GOF, and -HI variants. This test can be used in research and clinical laboratory settings.
Authors
- Megan Cooper (ORCID: https://orcid.org/0000-0001-8188-1652)
- Matías Oleastro
- Kristen McDaniels
- Silvia Danielian
- Joseph Pechacek
- Ana Esteve‐Solé (ORCID: https://orcid.org/0000-0002-0542-0587)
- S Rosenzweig
- Jennifer W. Leiding (ORCID: https://orcid.org/0000-0002-7573-9390)
- TA Fleisher
- Lisa Forbes Satter
- Tiphanie P. Vogel
- Luis Ignacio Gonzalez‐Granados
- Alexandra F. Freeman
- Steven M. Holland
- Hye Sun Kuehn
- Michail S. Lionakis
- Amy Hsu
- Taura Webb
- Carolina Bouso
Institutions
- Washington University in St. Louis (US)
- Garrahan Hospital (AR)
- Research Institute Hospital 12 de Octubre (ES)
- National Institute of Allergy and Infectious Diseases (US)
- Texas Children's Hospital (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Pediatric Allergy and Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/pai.70300
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00