Defining Important Aspects of Repigmentation in Vitiligo: Insights From Patients' Perspectives

Repigmentation is an essential outcome in vitiligo assessment, yet it remains broadly defined. While perspectives from vitiligo experts have been explored, gaining insights from patients is crucial for a more comprehensive understanding. Ultimately, this could contribute to the development and refinement of core outcome sets for vitiligo. This study aimed to determine aspects of repigmentation patients consider most important. Two surveys and one focus group were conducted, involving 34 patients/patient caregivers and 20 patient representatives. In the surveys, aspects were deemed important if ≥ 70% of participants rated them as such. The focus group used the nominal group technique to rank the five most important self-suggested aspects. The survey results indicate reduction of target lesion surface area, maintenance of repigmentation, and cessation of spread as important. The focus group identified additional aspects, including "time to repigment," "location of lesions," and "color match". This study identified key aspects of repigmentation important to vitiligo patients. While survey results in general aligned with the core domain set for vitiligo clinical trials, the focus group highlighted additional factors. Incorporating these patient-centered priorities into future core outcome sets could enhance the clinical relevance of vitiligo research and ensure outcomes reflect patient perspectives.

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Publication Details

Journal
Pigment Cell & Melanoma Research
Published
2026-02-05
DOI
https://doi.org/10.1111/pcmr.70078
Primary Topic
melanin and skin pigmentation
Type
article
Field-Weighted Citation Impact
0.00

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article

Defining Important Aspects of Repigmentation in Vitiligo: Insights From Patients' Perspectives

Liesbeth Delbaere, Alex Schneider, Nicoline F. Post, J.‐M. Meurant et al.
Pigment Cell & Melanoma Research
melanin and skin pigmentation
article

Defining Important Aspects of Repigmentation in Vitiligo: Insights From Patients' Perspectives

Liesbeth Delbaere, Alex Schneider, Nicoline F. Post, J.‐M. Meurant, S.E. Uitentuis, Caroline B. Terwee, I. Hamzavi, Amit Garg, Reinhart Speeckaert, Julien Sénéschal, M. Zuidgeest, Georg Pliszewski, Nicolle Maquignon, Phyllis Spuls, Emma Rush, Marlide R. Jukema, Sharon King, Paul Monteiro, Nathalie Ambersley, Maya Tulpule, Stephen Taylor, Sandrine Herbelet, Jolien Duponselle, Nanja van Geel
article en

Abstract

Repigmentation is an essential outcome in vitiligo assessment, yet it remains broadly defined. While perspectives from vitiligo experts have been explored, gaining insights from patients is crucial for a more comprehensive understanding. Ultimately, this could contribute to the development and refinement of core outcome sets for vitiligo. This study aimed to determine aspects of repigmentation patients consider most important. Two surveys and one focus group were conducted, involving 34 patients/patient caregivers and 20 patient representatives. In the surveys, aspects were deemed important if ≥ 70% of participants rated them as such. The focus group used the nominal group technique to rank the five most important self-suggested aspects. The survey results indicate reduction of target lesion surface area, maintenance of repigmentation, and cessation of spread as important. The focus group identified additional aspects, including "time to repigment," "location of lesions," and "color match". This study identified key aspects of repigmentation important to vitiligo patients. While survey results in general aligned with the core domain set for vitiligo clinical trials, the focus group highlighted additional factors. Incorporating these patient-centered priorities into future core outcome sets could enhance the clinical relevance of vitiligo research and ensure outcomes reflect patient perspectives.

Pigment Cell & Melanoma ResearchVol. 39(2)
Centre National de la Recherche Scientifique (FR), Henry Ford Health System (US), Allgemeiner Deutscher Automobil Club (DE), Ghent University Hospital (BE), Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US), Amsterdam Neuroscience (NL), Hôpital Saint-André (FR), Maharashtra Association of Anthropological Sciences (IN), Vitiligo and Pigmentation Institute of Southern California (US), International Office for Water (FR), Association of universities in the Netherlands (NL), Public Health Service of Amsterdam (NL), Amsterdam University Medical Centers (NL)
Incyte, Vlaamse regering
Openalex Percentile: Top 68%
melanin and skin pigmentation
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