Genotype-specific communication profiles in 79,518 individuals with neurodevelopmental disorders
These findings underscore the potential of precision speech-language pathology (SLP) approaches tailored to the specific verbal and nonverbal communication strengths and weaknesses of genetic groups. We also provide evidence for measurable improvements and declines in communication abilities with age at the group level, highlighting the need for developmentally informed care. By integrating genetic insights into clinical practice, precision SLP approaches may enhance communication outcomes and developmental progress and improve quality of life for individuals with genetic NDDs.
Authors
- Andrés Jiménez-Gómez (ORCID: https://orcid.org/0000-0001-6071-2833)
- Natasha N. Ludwig (ORCID: https://orcid.org/0000-0002-8934-7267)
- Alina Ivaniuk (ORCID: https://orcid.org/0000-0001-9912-3112)
- Ana Arenivas
- Cristiane Hsu
- Dennis Lal (ORCID: https://orcid.org/0000-0003-2591-432X)
- Tobias Brunger
- M. Scott Perry
- Chiara Phan
Institutions
- Broad Institute (US)
- Kennedy Krieger Institute (US)
- Memorial Hermann (US)
- Memorial Hermann Institute for Rehabilitation and Research Foundation (US)
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Jacksonville College (US)
- Cook Children's Medical Center (US)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- Japan Society (US)
- The University of Texas Health Science Center (US)
- The Neurological Institute (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-04
- DOI
- https://doi.org/10.64898/2026.02.03.26345484
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke