Exosomes derived from bone marrow mesenchymal stem cells attenuate OGD/R-induced apoptosis in PC-12 cells via activation of the PI3K/AKT pathway
Exosomes derived frvom BMSC effectively inhibitedp aupoptposis induced by OpGD/R through uactivation of the PI3K/Akt. Although HP significantly enhanced the secretion of exosomes from BMSC, it did not improve the therapeutic efficacy of these exosomes when administered at an equivalent dosage.
Authors
- Haibin Shi (ORCID: https://orcid.org/0000-0003-2234-9126)
- Xinxin Huang (ORCID: https://orcid.org/0000-0002-4298-4859)
- Bin Leng (ORCID: https://orcid.org/0009-0007-5370-342X)
- Xing-Long Liu (ORCID: https://orcid.org/0000-0002-1796-4653)
- Sheng Liu (ORCID: https://orcid.org/0000-0003-4724-4988)
- Run‐Hao Jiang
Institutions
- Jiangsu Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Stem Cells and Regenerative Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.46582/jsrm.2201002
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing Medical University