Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model

Quercetin alleviates gp120-induced intestinal barrier disruption via inhibition of the ERK1/2-MLCK signaling pathway and restoration of tight junction proteins. These findings highlight the therapeutic potential of Quercetin as a natural compound to protect against HIV-related mucosal injury and support its further development for managing HIV-associated comorbidities.

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Publication Details

Journal
AIDS Research and Therapy
Published
2026-02-06
DOI
https://doi.org/10.1186/s12981-026-00846-9
Primary Topic
Barrier Structure and Function Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model

Jiangyu Yan, Jing Ouyang, Qinghui Wang, Lijiao Zhu et al.
AIDS Research and Therapy
Barrier Structure and Function Studies
article

Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model

Jiangyu Yan, Jing Ouyang, Qinghui Wang, Lijiao Zhu, Jiadan Yang, Xiaolei Xu, Xiaoqing He
article en

Abstract

Quercetin alleviates gp120-induced intestinal barrier disruption via inhibition of the ERK1/2-MLCK signaling pathway and restoration of tight junction proteins. These findings highlight the therapeutic potential of Quercetin as a natural compound to protect against HIV-related mucosal injury and support its further development for managing HIV-associated comorbidities.

AIDS Research and TherapyVol. 23(1)
Southwest University (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Public Health Medical Center (CN), Chongqing Medical University (CN)
Natural Science Foundation of Chongqing, Centre Scientifique et Technique du Bâtiment
Good health and well-being
Openalex Percentile: Top 71%
Barrier Structure and Function Studies
DOIOpen Access PDFOpenAlex
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Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model — Jiangyu Yan, Jing Ouyang, et al. · AIDS Research and Therapy (2026) | TGRS Research Map | TGRS