Age and onset timing of Raynaud’s phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italia

The timing of RP and NRP onset may help define SSc endotype and survival. Patients with simultaneous RP-NRP onset have more severe disease features and higher mortality risk, emphasizing the relevance of onset timing in disease stratification.

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Publication Details

Journal
Therapeutic Advances in Musculoskeletal Disease
Published
2026-02-01
DOI
https://doi.org/10.1177/1759720x251410243
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
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article

Age and onset timing of Raynaud’s phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italia

E. Visalli, Giuseppina Abignano, V. Codullo, Gian Domenico Sebastiani et al.
Therapeutic Advances in Musculoskeletal Disease
Systemic Sclerosis and Related Diseases
article

Age and onset timing of Raynaud’s phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italia

E. Visalli, Giuseppina Abignano, V. Codullo, Gian Domenico Sebastiani, Anna Iuliano, Cosimo Bruni, Giorgio Pettiti, F. Lumetti, Silvia Laura Bosello, E. Rosato, Giuseppa Pagano Mariano, E. Lubrano, Amelia Spinella, Giuseppe Murdaca, Licia Vultaggio, M. Fornaro, Gianna Mennillo, Edoardo Cipolletta, Carlo Iandoli, Lorenzo DAGNA, S. D’angelo, Giovanni Zanframundo, Gerolamo Bianchi, Clara Lisa Peroni, Maria Grazia Lazzaroni, R. Foti, Giovanni Ciano, L. Beretta, A. Gigante, Fusaro Enrico, Maria De Santis, Franco Cozzi, Cecilia Agnes, Maurizio Santi Caminiti, Gianluca Bagnato, Simone Parisi, Alarico Ariani, Francesco Girelli, Luca Idolazzi, Ilenia De Andres, Greta Pellegrino, Corrado Campochiaro, Dilia Giuggioli, Ilaria Cavazzana, Marco Di Battista, Francesco Bonomi, Giovanna Cuomo, Marco Matucci-Cerinic, Andrea Doria, Valeria Riccieri, Florenzo Iannone, Giacomo De Luca, Federica Furini, Marcello Govoni, Alessandra Della Rossa, Silvia Peretti, Clodoveo Ferri, Carlo Salvarani, Elisabetta Zanatta, Francesca Ingegnoli, Gianluigi Bajocchi, Gemma Lepri, Erika Pigatto, Maria Antonietta D’Agostino, Marta Saracco, Enrico De Lorenzis, Serena Guiducci
article en

Abstract

The timing of RP and NRP onset may help define SSc endotype and survival. Patients with simultaneous RP-NRP onset have more severe disease features and higher mortality risk, emphasizing the relevance of onset timing in disease stratification.

Therapeutic Advances in Musculoskeletal DiseaseVol. 18
University of Pisa (IT), University of Messina (IT), University of Verona (IT), University of Modena and Reggio Emilia (IT), Marche Polytechnic University (IT), University of Molise (IT), Humanitas University (IT), University of Padua (IT), Vita-Salute San Raffaele University (IT), University of Milan (IT), University of Ferrara (IT), University of Basilicata (IT), University of Pavia (IT), Agostino Gemelli University Polyclinic (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ospedale San Paolo (IT), Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT), Ospedale Maggiore (IT), University Hospital of Zurich (CH), Ospedale San Carlo (IT), Istituto Clinico Sant'Ambrogio (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Istituto S.Anna Crotone (IT), Azienda Ospedaliero-Universitaria Careggi (IT), Biogem (IT), Ospedale G.B. Morgagni - L.Pierantoni (IT), Arcispedale Sant'Anna (IT), University of Campania "Luigi Vanvitelli" (IT), Torino e-district (IT), Policlinico Universitario di Catania (IT), Ospedale di Parma (IT), LUM Jean Monnet University (IT), Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT), Sydney Local Health District (AU), Ospedale Generale Regionale Francesco Miulli (IT), Azienda di Rilievo Nazionale ed Alta Specializzazione (IT), Policlinico San Matteo Fondazione (IT), University of the Sacred Heart (JP), Carlo Forlanini Hospital (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Villa Torri Hospital (IT), University of Florence (IT), University of Bari Aldo Moro (IT), University of Brescia (IT), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 67%
Systemic Sclerosis and Related Diseases
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