Activity of chemotherapy in mesenchymal chondrosarcoma: a multicentre retrospective analysis within the Italian Sarcoma Group network
This multicentre study confirms that anthracycline-based regimens show activity in MCS, with responses more in line with soft tissue sarcoma than Ewing sarcoma. Their benefit in localized disease remains uncertain, but (neo)adjuvant chemotherapy with Ewing-like regimens should be considered for patients eligible for surgery. In advanced disease, trabectedin may provide prolonged disease control after anthracyclines.
Authors
- M. Sbaraglia
- Matteo Benelli (ORCID: https://orcid.org/0000-0003-1227-356X)
- Nadia Puma (ORCID: https://orcid.org/0000-0002-9743-2808)
- P.G. Casali
- Chiara Biagioni (ORCID: https://orcid.org/0000-0002-7908-4854)
- S. Bazzurri
- G. Dagrada
- S. Aliberti (ORCID: https://orcid.org/0000-0001-6990-9341)
- Carlo Morosi (ORCID: https://orcid.org/0000-0003-4940-2185)
- GM Milano
- Manuela Cesari
- Antonella Brunello
- G.G. Baldi
- A. Franchi
- S.D. Asaftei
- D.A. Campanacci
- S. Stacchiotti
- A.M. Frezza
- B. Vincenzi
- R.M. Kelaney
- M. Gambarotti
- G. Bianchi
- A. Gronchi
Institutions
- Ain Shams University (EG)
- University of Pisa (IT)
- Università Campus Bio-Medico (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Istituto Ortopedico Rizzoli (IT)
- Bambino Gesù Children's Hospital (IT)
- Ospedale Regina Margherita (IT)
- Azienda Ospedale - Università Padova (IT)
- Candiolo Cancer Institute (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Hospital of Prato (IT)
- University of Florence (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.esmoop.2026.106080
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00