Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene ( <i>Akap5</i> ) epigenetic modifications
Maternal exercise improves blood pressure and vascular function in adult male hypertensive offspring by deacetylating H3K9ac at the Akap5 promoter via AMPK/SIRT1 activation. This highlights prenatal exercise as a potential strategy to mitigate the intergenerational transmission of hypertension.
Authors
- Fang Qiu
- ZhaoXia Xu
- Xiaozhen Ding
- Meiling Shan
- Lijun Shi
- Xiaodong Liu
- Yanyan Zhang
- Jiaqi Cao
- Zihan Fan
Institutions
- Shanghai International Studies University (CN)
- General Administration of Sport of China (CN)
- Beijing Sport University (CN)
- Shanghai University of International Business and Economics (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1111/bph.70346
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Universities Scientific Fund