2′,4′-dihydroxychalcone alleviates inflammatory bowel disease by inhibiting NLRP3 inflammasome and modulating gut microbiota
Overall, this study identified 2',4'-DHC in ACH that regulated the NLRP3 inflammasome activation to exert anti-inflammatory effects in IBD, highlighting its potential in treating NLRP3-related inflammatory diseases.
Authors
- Hua Yu (ORCID: https://orcid.org/0000-0003-0737-9925)
- Jian Xiao
- Jingqi Wang (ORCID: https://orcid.org/0009-0006-9472-0667)
- Chun Yao
- Yixin Yao
- Hua Luo
- Mingqing Huang
- Yitao Wang
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- University of Macau (MO)
- Guangxi University of Chinese Medicine (CN)
- Ministry of Education (TH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1751218
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00