Interplay between Peripheral and Central Nervous System Myeloid Cells during Aging: Impact for Lade-Life Depression and Alzheimer’s Disease
The cumulative impact of these alterations undermines neuroprotection and facilitates age-related neuropsychiatric conditions, including neurodegenerative diseases and late-life depression. The identification of pro-aging circulating factors and cells could pave the way for new therapeutic strategies aimed at mitigating cognitive decline and improving mood. Targeting myeloid cell metabolism or inflammatory signaling pathways emerges as a promising strategy to mitigate aging-associated neuropsychiatric syndromes.
Authors
- Aline Silva de Miranda (ORCID: https://orcid.org/0000-0003-2811-7924)
- Érica Leandro Marciano Vieira (ORCID: https://orcid.org/0000-0002-4147-5614)
- Moisés Evandro Bauer
- Antonio Carlos Silva Costa Teixeira
Institutions
- Universidade Federal de Minas Gerais (BR)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Centre for Addiction and Mental Health (CA)
- The University of Texas at San Antonio Health Science Center (US)
- University of Toronto (CA)
- Institute for Neurodegenerative Disorders (US)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Publication Details
- Journal
- NeuroImmunoModulation
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1159/000550781
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00