Disseminated classic Kaposi sarcoma

An older man presented with rapidly progressive violaceous reticulated plaques on the limbs. He was ultimately diagnosed with Kaposi sarcoma after multiple biopsies and confirmation of human herpesvirus-8 on immunohistochemistry. He demonstrated an unusually rapid and widespread presentation of classic Kaposi sarcoma, which typically follows a slower and more localized course. We highlight the importance of early recognition, repeat biopsy when clinical suspicion persists and multidisciplinary management to guide appropriate care.