Distinct activation thresholds of unmyelinated C-fiber afferents by dorsal root ganglion and peripheral nerve stimulation
These findings identify a structural and molecular mechanism underlying the efficient activation of C-fiber afferents by DRG stimulation and provide mechanistic insight into the superior therapeutic efficacy of DRG stimulation for the treatment of C-fiber-mediated chronic pain.
Authors
- Shaopeng Zhang (ORCID: https://orcid.org/0000-0002-1222-2992)
- Sajjad Rigi Ladez
- Bin Feng
- Longtu Chen
- Jia Liu
Institutions
- University of Connecticut (US)
- University of Maryland Eastern Shore (US)
- Immunomedics (Germany) (DE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-04
- DOI
- https://doi.org/10.64898/2026.02.02.703367
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institute of Biomedical Imaging and Bioengineering