Thyroid hormone deficiency induces endolymphatic hydrops: neurological and histopathological evidence from an experimental rat model
This study provides the first direct experimental evidence that thyroid hormone deficiency induces endolymphatic hydrops in all examined vestibular structures. These findings establish a mechanistic link between hypothyroidism and vestibular pathology, with important implications for the neurological evaluation and management of patients presenting with vestibular symptoms and comorbid thyroid dysfunction.
Authors
- Eray Metin Güler (ORCID: https://orcid.org/0000-0003-4351-1719)
- Serap Önder (ORCID: https://orcid.org/0000-0002-3576-0953)
- Sahin Yilmaz A
- Mehmet Surmeli
- Gizem Meral Kantarci (ORCID: https://orcid.org/0000-0002-9437-0795)
- Elif Gelenli Dolanbay
- Hacer Inan Gungor
Institutions
- Acıbadem University (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Istanbul Medeniyet University (TR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fneur.2026.1774666
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00