Bridging cognitive reserve and cerebellar networks: counteracting brain damage in patients with Alzheimer’s disease at different clinical stages
These findings provide evidence of progressive cerebellar-cortical disconnection in AD pathology and highlight cerebellar reserve as a potential protective factor, suggesting that the CbCR assessment and specific interventions tailored to the cerebellar cognitive functions may help delay the cognitive decline.
Authors
- Francesca Gelfo (ORCID: https://orcid.org/0000-0002-3935-2164)
- Giulia Caruso
- Sabrina Bonarota (ORCID: https://orcid.org/0009-0008-5514-9108)
- Carlotta Di Domenico (ORCID: https://orcid.org/0000-0001-8060-1663)
- Martina Rizzuti
- Federico Giove
- Laura Petrosini
- Laura Serra
- Matteo Mancini
- Carlo Caltagirone
Institutions
- Marconi University (IT)
- Centro Ricerche Enrico Fermi (IT)
- Fondazione Santa Lucia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fncel.2026.1716783
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission