Updated Treatment of Non‐Steroidal Anti‐Inflammatory Drug‐Exacerbated Respiratory Disease: How to Decide on Aspirin Therapy After Desensitization or Biologics? When? How? An <scp>EAACI</scp> Task Force Report
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NSAID-ERD) is a heterogeneous condition characterized by chronic eosinophilic airway inflammation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma whose symptoms are aggravated after ingestion of aspirin and other NSAIDs. As a unique treatment, aspirin treatment after desensitization (ATAD) has been in use for several years after showing the inhibitory effect on CRS symptoms and nasal polyp growth as well as severe asthma. However, in recent years, biologics have also shown to cause a decrease in polyp size as well as associated outcomes such as quality of life. In this manuscript, considerations on choosing the best treatment of NSAID-ERD are laid out based on current literature.
Authors
- Katharine M. Woessner
- Tanya M. Laidlaw (ORCID: https://orcid.org/0000-0001-6709-9795)
- G Celik
- Joanna Makowska (ORCID: https://orcid.org/0000-0003-2036-375X)
- A Vultaggio
- Ömür Aydın (ORCID: https://orcid.org/0000-0002-8531-2550)
- S. Toppila‐Salmi
- Annick Barbaud
- Maria Jose Torres
- Ludger Klimek
- Lene Heise Garvey
- Aslı Gelincik
- Thomas Eiwegger
Institutions
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- University of Helsinki (FI)
- Ankara University (TR)
- Inserm (FR)
- University of Eastern Finland (FI)
- University of Toronto (CA)
- Savonia University of Applied Sciences (FI)
- Hospital for Sick Children (CA)
- Gentofte Hospital (DK)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospital Regional Universitario de Málaga (ES)
- Scripps Clinic Medical Group (US)
- Universitätsklinikum St. Pölten (AT)
- Zentrum für Rhinologie und Allergologie (DE)
- Medical University of Lodz (PL)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Allergy and Asthma Medical Group and Research Center (US)
- Karl Landsteiner University of Health Sciences (AT)
- Instituto de Investigación Biomédica de Málaga (ES)
- Hospital District of Helsinki and Uusimaa (FI)
- Hôpital Tenon (FR)
- University of Florence (IT)
- Istanbul University (TR)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Allergy
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1111/all.70243
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00