Pentraxin 3 deficiency exacerbates neutrophilic inflammation and airway hyperresponsiveness in type 2-low asthma
PTX3 absence enhances neutrophilic inflammation, IL-17A production, IgE responses, and AHR, highlighting PTX3 as a potential biomarker and therapeutic target in type 2- low asthma.
Authors
- Andrew J. Halayko (ORCID: https://orcid.org/0000-0002-7865-4552)
- Sina Taefehshokr (ORCID: https://orcid.org/0000-0002-8949-0493)
- Mojdeh Matloubi
- Abdelilah S. Gounni (ORCID: https://orcid.org/0000-0003-1265-6560)
- Sujata Basu
- Lianyu Shan
Institutions
- University of Manitoba (CA)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/falgy.2026.1731295
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research