Application of nanoparticles in antibody drug delivery

Due to their special molecular weight and pharmacokinetic/pharmacodynamic (PK/PD) characteristics, antibody drugs have difficulty crossing the body barrier and entering complex microenvironments to provide effective treatment for encephalopathy, cancer, and severe infectious diseases. With the development and application of nanotechnology, drugs can be modified by nanomethods to increase the delivery efficiency, targeting, and permeability, reduce the resistance to the antibody, and improve the response rate, thus increasing their safety and effectiveness. Therefore, nanoparticles have extensive research and application value in drug delivery systems. This article summarizes the characteristics of nanoparticles and nanoantibody delivery systems to provide a reference for the future application of nanoparticles in drug delivery.

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Journal
Frontiers in Bioengineering and Biotechnology
Published
2026-02-05
DOI
https://doi.org/10.3389/fbioe.2026.1759915
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
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article

Application of nanoparticles in antibody drug delivery

Xuejun Xiao, Qingmei Zhu, Nadira Dolkun, Wumiti Xiefukaiti
Frontiers in Bioengineering and Biotechnology
Nanoparticle-Based Drug Delivery
article

Application of nanoparticles in antibody drug delivery

Xuejun Xiao, Qingmei Zhu, Nadira Dolkun, Wumiti Xiefukaiti
article en

Abstract

Due to their special molecular weight and pharmacokinetic/pharmacodynamic (PK/PD) characteristics, antibody drugs have difficulty crossing the body barrier and entering complex microenvironments to provide effective treatment for encephalopathy, cancer, and severe infectious diseases. With the development and application of nanotechnology, drugs can be modified by nanomethods to increase the delivery efficiency, targeting, and permeability, reduce the resistance to the antibody, and improve the response rate, thus increasing their safety and effectiveness. Therefore, nanoparticles have extensive research and application value in drug delivery systems. This article summarizes the characteristics of nanoparticles and nanoantibody delivery systems to provide a reference for the future application of nanoparticles in drug delivery.

Frontiers in Bioengineering and BiotechnologyVol. 14
Xinjiang Medical University (CN), Xinjiang Institute of Materia Medica (CN)
Good health and well-being
Openalex Percentile: Top 68%
Nanoparticle-Based Drug Delivery
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Application of nanoparticles in antibody drug delivery — Xuejun Xiao, Qingmei Zhu, et al. · Frontiers in Bioengineering and Biotechnology (2026) | TGRS Research Map | TGRS