Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients

Overall, our study showed that resting-state fMRI from patients after glioma resection is relevant to their long-term neurological outcomes: decreased connectivity in the perilesional regions compared to the contralateral regions indicates less survival time and worsened functional outcomes. The reported analytics from postsurgical fMRI scans, combined with the machine learning model, could provide important prognostic information for postsurgical recovery management.

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Publication Details

Journal
Frontiers in Neuroscience
Published
2026-02-05
DOI
https://doi.org/10.3389/fnins.2026.1751746
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients

Tressie M. Stephens, Alissa Schroeder, Ian F. Dunn, Lei Ding et al.
Frontiers in Neuroscience
Functional Brain Connectivity Studies
article

Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients

Tressie M. Stephens, Alissa Schroeder, Ian F. Dunn, Lei Ding, Derek Madden, Mingwei Huang, Han Yuan
article en

Abstract

Overall, our study showed that resting-state fMRI from patients after glioma resection is relevant to their long-term neurological outcomes: decreased connectivity in the perilesional regions compared to the contralateral regions indicates less survival time and worsened functional outcomes. The reported analytics from postsurgical fMRI scans, combined with the machine learning model, could provide important prognostic information for postsurgical recovery management.

Frontiers in NeuroscienceVol. 20
Stephens College (US), Institute for Biomedical Engineering (CH), University of Oklahoma Health Sciences Center (US)
University of Oklahoma, National Institutes of Health, University of Oklahoma Health Sciences Center, National Institute of General Medical Sciences
Openalex Percentile: Top 66%
Functional Brain Connectivity Studies
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