Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8+T cell infiltration mediated by Rela/NF-kB-Cxcl9 axis
XYS directly targets and activates the intratumoral Rela/NF-κB-Cxcl9 axis, promoting CD8<sup>+</sup>T cell infiltration and activation, thereby inhibiting the growth of ED-TNBS.
Authors
- Lingling Ye (ORCID: https://orcid.org/0000-0001-6359-1678)
- Junfeng Huang (ORCID: https://orcid.org/0000-0003-0984-9505)
- Huan Shi (ORCID: https://orcid.org/0000-0002-7520-8776)
- Yz Liang
- Xue Song (ORCID: https://orcid.org/0000-0001-9846-9189)
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Zhuang Li (ORCID: https://orcid.org/0000-0002-7093-4904)
- Yunlong Bai
- Juexiao Zeng
- Yan Dai
- Qian Zuo
- Qianjun Chen
- Yingchao Wu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Ji Hua Laboratory (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1762492
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University