ChitoSilkBioPatch: A bio‐inspired wound dressing scaffold for antibiotic‐free diabetic wound management

Abstract Delayed wound healing in diabetic patients poses significant clinical challenges, increasing risks of severe foot infections and potential limb amputation. To address infection risks and antibiotic resistance, we developed an antibiotic‐free composite, “ChitoSilkBioPatch,” integrating maleimide‐releasing chitosan hydrogels with decellularized fetal membrane (dACM) and a biomimetic stretchable silk mesh. This innovative scaffold combines potent antibacterial activity against Gram‐positive ( Staphylococcus aureus ) and Gram‐negative ( Pseudomonas aeruginosa ) bacteria through nanotopographical cues, dACM, oligochitosan, and conjugated maleimides, alongside robust regenerative properties. The silk mesh mimics skin's tensile strength and stretchability, while the hydrogel provides viscoelasticity akin to skin. In vivo, ChitoSilkBioPatch demonstrates strong anti‐inflammatory effects, accelerates epidermal and dermal regeneration, and enhances angiogenesis and immunomodulation, offering a promising solution for chronic diabetic wound healing.