Antibacterial and anti-virulence effects of <i>Saxifraga stolonifera</i> Meeb extracts against <i>Pseudomonas aeruginosa</i>
<i>Pseudomonas aeruginosa</i> infections pose severe challenges to clinical treatment, and anti-virulence therapy has emerged as a novel therapeutic strategy. This study demonstrates that the n-butanol extract of <i>Saxifraga stolonifera</i> exerts anti-virulence effects by downregulating virulence-related genes, inhibiting quorum-sensing systems, and biofilm formation. Moreover, its multiple bioactive components also possess antibacterial and anti-virulence properties. <i>S. stolonifera</i> is thus promising to be developed into a novel anti-virulence inhibitor against <i>P. aeruginosa</i> for the prevention and treatment of clinically relevant infections.
Authors
- Qing Peng (ORCID: https://orcid.org/0000-0002-2238-8400)
- Yu‐Chen Huang (ORCID: https://orcid.org/0000-0001-6682-4035)
- Yijing Zhuang
- Weidong Chen (ORCID: https://orcid.org/0000-0002-8228-331X)
- Zijie Zhang (ORCID: https://orcid.org/0000-0003-2757-3071)
- Fen Yao (ORCID: https://orcid.org/0000-0002-4959-0916)
- Qin He
- Yuxiang Hong
- Lin Chen
- Lei Liu
- Yue Li
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Technion – Israel Institute of Technology (IL)
- Shantou University (CN)
- Longgang Central Hospital (CN)
- The Third People's Hospital of Dalian City (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1128/spectrum.02821-25
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province