Assessment of genome evolution in <i>Bifidobacterium adolescentis</i> indicates genetic adaptation to the human gut
To comprehensively explore the biodiversity within a microbial species, the reconstruction of a substantial number of genomes is essential. In this study, we successfully uncovered the genetic diversity of <i>Bifidobacterium adolescentis</i> by retrieving a large number of genomes from human gut metagenomic samples. The complete overview of the <i>B. adolescentis</i> pangenome enabled us to investigate the genetic features that distinguish this gut commensal from other bifidobacterial species residing in the human intestinal microbiota.
Authors
- Hilary P. Browne (ORCID: https://orcid.org/0000-0002-1305-2470)
- Gabriele Andrea Lugli (ORCID: https://orcid.org/0000-0002-3024-0537)
- Marco Ventura
- Christian Milani (ORCID: https://orcid.org/0000-0002-5062-3164)
- Yan Shao (ORCID: https://orcid.org/0000-0002-8662-0504)
- Chiara Tarracchini (ORCID: https://orcid.org/0000-0003-2578-0050)
- Kaede V. Sullivan (ORCID: https://orcid.org/0000-0001-6654-5861)
- Leonardo Mancabelli (ORCID: https://orcid.org/0000-0002-1744-2214)
- Silvia Petraro
- Emanuele Selleri
- Douwe van Sinderen
- Francesca Turroni
Institutions
- University of Parma (IT)
- National University of Ireland (IE)
- Wellcome Sanger Institute (GB)
- APC Microbiome Institute (IE)
Publication Details
- Journal
- mSystems
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1128/msystems.01173-25
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00