ESRP1 drives epithelial-mesenchymal transition by activating EPAC-RAP1A signaling axis
Our findings demonstrate that ESRP1 upregulation in alveolar epithelial cells drives IPF progression by promoting EMT via the Epac-Rap1a axis.
Authors
- Jingwei Yu (ORCID: https://orcid.org/0000-0002-7587-754X)
- Jianjun Wang (ORCID: https://orcid.org/0000-0001-7039-7136)
- Tingting Zhao
- Ruixin Qi
- Juan Chen
- Guocang Cheng
- Zhengyu Hu
Institutions
- Deyang Stomatological Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fmed.2026.1734619
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project