Clinical hypnosis for velo-cardio-facial syndrome: A case series and therapeutic framework

Velo-Cardio-Facial Syndrome (VCFS) is associated with significant psychological and psychiatric comorbidities, including anxiety, depression, and psychosis. This case series explores the use of clinical hypnosis as a treatment to attenuate comorbid mental symptoms and enhance quality of life for individuals with VCFS. Sixteen cases aged 6 to 38 with genetically confirmed VCFS and psychological disorders were taught self-hypnosis and positive reframing. Caregivers assisted participants with practicing self-hypnosis and monitoring progress. Outcomes were assessed qualitatively based on symptomatic improvements reported by caregivers and patients across clinical visits. Treatment efficacy appeared influenced by patient engagement, caregiver support, and strategically directed hypnotic suggestions. Findings suggest therapy with hypnosis appears to be a low-cost, non-pharmacological approach for reducing anxiety, improving emotional-regulation, and alleviating some psychotic symptoms in VCFS.