The transcriptomic signature of age and sex is not conserved in human primary myotubes
The diversity of resident cell populations in muscle tissue and the lack of sex- and age-dependent circulating factors in the cellular milieu likely contribute to these observations, which call for caution when using differentiated HPMCs as an experimental model of human muscle sex or age.
Authors
- Megan Soria (ORCID: https://orcid.org/0000-0002-8715-6854)
- Akriti Varshney
- Mark Ziemann (ORCID: https://orcid.org/0000-0002-7688-6974)
- Annabel J. Critchlow (ORCID: https://orcid.org/0000-0002-2039-9528)
- Danielle Hiam (ORCID: https://orcid.org/0000-0003-0135-329X)
- Lamon Séverine
- Karel Van Belleghem
- Traude Beillharz
- Andrew Garnham
- Ross Williams
Institutions
- Burnet Institute (AU)
- Deakin University (AU)
- Discovery Institute (US)
- Murdoch Children's Research Institute (AU)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1186/s13395-026-00416-7
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Burnet Institute
- Novo Nordisk
- Australian Research Data Commons