Preparation of α-Chloroketones via Oxo/Chloro Difunctionalization of Unactivated Alkenes under Mild Conditions

A one-step synthesis of α-chloroketones via transition metal-free-mediated oxo/chloro difunctionalization of unactivated alkenes using <i>N</i>-chloro-<i>N</i>-fluorobenzenesulfonamide (CFBSA) is reported, and both aromatic and aliphatic alkenes can be efficiently converted into their corresponding α-chloroketones by simply choosing different conditions. This reaction system has several characteristics such as a wide substrate scope, excellent functional group tolerance, mild conditions, low cost, and good yield stability in scale-up reactions, broadening the methodology for the late-stage modification of drugs and natural products.