FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Our work provides new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

Authors

Nikita Chugh
D. G. McDonald
Martin L. Duennwald (ORCID: https://orcid.org/0000-0002-9136-4592)
Rares Sava

Institutions

Western University (CA)

Publication Details

Journal: BMC Biology
Published: 2026-02-06
DOI: https://doi.org/10.1186/s12915-026-02537-3
Primary Topic: Genetics, Aging, and Longevity in Model Organisms
Type: article
Field-Weighted Citation Impact: 0.00

Funders

McGill University
ALS Society of Canada
Marquette University
University of Toronto
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
CIHR Skin Research Training Centre

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article

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Nikita Chugh, D. G. McDonald, Martin L. Duennwald, Rares Sava

Feb 6, 2026

BMC Biology

Genetics, Aging, and Longevity in Model Organisms

article

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Nikita Chugh, D. G. McDonald, Martin L. Duennwald, Rares Sava

February 6, 2026article en

Abstract

Our work provides new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

BMC BiologyVol. 24(1)

Western University (CA)

McGill University, ALS Society of Canada, Marquette University, University of Toronto, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, CIHR Skin Research Training Centre

Zero hunger

Openalex Percentile: Top 66%

Genetics, Aging, and Longevity in Model Organisms

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FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models — Nikita Chugh, D. G. McDonald, et al. · BMC Biology (2026) | TGRS Research Map | TGRS