Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis
We observed consistent associations of accelerated DunedinPACE with multiple cardiometabolic conditions. All epigenetic clocks showed associations of epigenetic age acceleration with diabetes. These findings emphasize the need for longitudinal analyses to determine the direction and causality of these relationships.
Authors
- Melissa Chapnick (ORCID: https://orcid.org/0000-0003-4674-7727)
- Lisa R. Staimez
- A. David Smith (ORCID: https://orcid.org/0000-0002-1095-6722)
- Elaine A. Yu (ORCID: https://orcid.org/0000-0003-2433-9562)
- Manuel Ramírez-Zea
- Karen N. Conneely
- Aryeh D. Stein
- Viola Vaccarino
Institutions
- Emory University (US)
- University of California, San Francisco (US)
- Pacific Research Institute (US)
- Woodruff Health Sciences Center (US)
- Vitalant (US)
- Institute of Nutrition of Central America and Panama (GT)
- University of San Francisco (US)
Publication Details
- Journal
- Journal of Health Population and Nutrition
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s41043-026-01255-4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- National Institutes of Health