Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms
This study elucidates how CAMs reshape the activation landscape of D2R and establishes a broadly applicable computational-experimental framework for discovering constitutively active GPCR variants. These CAMs provide valuable ligand-independent models for probing receptor activation mechanisms at structural, cellular, and physiological levels.
Authors
- Lucie Delemotte (ORCID: https://orcid.org/0000-0002-0828-3899)
- Y. Chen
- Akshay Naraine (ORCID: https://orcid.org/0000-0001-8231-2240)
- Marcus Saarinen (ORCID: https://orcid.org/0000-0001-9019-8396)
- Jörgen Carlsson
- Per Svenningsson
Institutions
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s12915-026-02542-6
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00