Recurrent Pregnancy Loss and Adverse Outcomes in Chronic Intervillositis of Unknown Etiology: A Systematic Review and Meta‐Analysis

CIUE is closely associated with pregnancy loss, fetal growth restriction, and perinatal death and is characterized by a high recurrence rate of approximately 40% in subsequent pregnancies, underscoring its clinical importance in women with unexplained RPL. Early pathological recognition and individualized surveillance may improve pregnancy management and counseling. Further multicenter prospective studies are warranted to define optimal diagnostic and therapeutic strategies.

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Publication Details

Journal
Journal of obstetrics and gynaecology research
Published
2026-02-01
DOI
https://doi.org/10.1111/jog.70195
Primary Topic
Reproductive System and Pregnancy
Type
article
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article

Recurrent Pregnancy Loss and Adverse Outcomes in Chronic Intervillositis of Unknown Etiology: A Systematic Review and Meta‐Analysis

Shuang Wu
Journal of obstetrics and gynaecology research
Reproductive System and Pregnancy
article

Recurrent Pregnancy Loss and Adverse Outcomes in Chronic Intervillositis of Unknown Etiology: A Systematic Review and Meta‐Analysis

Shuang Wu
article en

Abstract

CIUE is closely associated with pregnancy loss, fetal growth restriction, and perinatal death and is characterized by a high recurrence rate of approximately 40% in subsequent pregnancies, underscoring its clinical importance in women with unexplained RPL. Early pathological recognition and individualized surveillance may improve pregnancy management and counseling. Further multicenter prospective studies are warranted to define optimal diagnostic and therapeutic strategies.

Journal of obstetrics and gynaecology researchVol. 52(2)
Qiannan Normal College For Nationalities (CN)
Good health and well-being
Openalex Percentile: Top 65%
Reproductive System and Pregnancy
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