1-Deoxynojirimycin with theaflavins ameliorates high-fat diet-induced insulin resistance in mice by modulating the gut microbiota
The combined administration of 1-DNJ and TFs demonstrated superior efficacy in ameliorating HFD-induced IR compared to individual components, with gut microbiota modulation playing a pivotal role. These findings position 1-DNJ and TFs as promising natural candidates for functional food development targeting metabolic health.
Authors
- Yichun Zhu
- Lixin Na Na
- Ti Yang (ORCID: https://orcid.org/0009-0008-7353-4077)
- Chenyang Song (ORCID: https://orcid.org/0000-0002-0484-9533)
- Yiwen Zhao (ORCID: https://orcid.org/0009-0009-7564-869X)
- Jingyi Zhang
- Qiannan Di
- Wenqing Li
- Chunbo Qu
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Aerospace Information Research Institute (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fnut.2025.1690747
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00