Single-cell transcriptomic profiling of peripheral blood mononuclear cells reveals monocyte heterogeneity in patients with Moyamoya disease
This study provides a comprehensive analysis of peripheral immune cell alterations in MMD, highlighting the involvement of monocyte subpopulations and specific signaling pathways in disease pathogenesis. The findings offer new insights into the immune dysregulation in MMD and suggest potential targets for diagnosis and treatment.
Authors
- Shuhua Zhang (ORCID: https://orcid.org/0009-0001-1048-1077)
- Jinjing Wu (ORCID: https://orcid.org/0000-0001-9686-7167)
- Xingpeng Qiu (ORCID: https://orcid.org/0009-0006-3698-2036)
- Jian Yan
- Jinlin Xiao (ORCID: https://orcid.org/0009-0007-2597-8928)
- Haizhou Miu
- Erming Zeng (ORCID: https://orcid.org/0009-0001-6227-1012)
- Daya Luo
- Youping Li
- Liwen Wei
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Jiangxi Pingxiang People's Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s13023-026-04241-5
- Primary Topic
- Moyamoya disease diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Key Research and Development Program of Jiangxi Province